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HESI A2

Anatomy.

Anatomy questions from the HESI A2 track.

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Post-NGN questions with verified answers and rationales. This is the core drill.

Which structure transports urine from the kidney to the bladder?

  • aUreterCorrect
  • bUrethra
  • cCollecting duct
  • dProstate
Rationale

Ureter. The ureter conveys urine from the kidneys to the bladder.   The urethra transports urine from the bladder to the exterior.   The collecting duct transports urine from the distal convoluted tubule to the renal pelvis. The prostate is part of the male reproductive system and its secretions constitute about 20% of the semen.   Structure Function Ureter A muscular tube that conveys urine from the renal pelvis to the bladder Bladder A muscular sac that stores urine until micturition Urethra A muscular tube that conveys urine from the bladder to the exterior

Source recency: 2026

What is the functional unit of the kidney?

  • aNephronCorrect
  • bGlomerulus
  • cTubules
  • dUreter
Rationale

Nephron. The nephron is the functional unit of the kidney.    There are about one million nephrons in each kidney. Each nephron is made up of the glomerulus and the tubule.  Blood is filtered across the glomerulus of each nephron and the glomerular filtrate is altered by the process of reabsorption and secretion as the filtrate moves down the tubules into the collecting duct. The collecting ducts empty urine into the renal pelvis. Urine moves from the renal pelvis to the ureter and into the bladder where it is stored until the person has an urge to urinate.    The glomerulus is not the functional unit of the kidney. Instead, it is a part of the nephron and the nephron is the functional unit of the kidney.   The tubule is not the functional unit of the kidney. Instead, it is a part of the nephron and the nephron is the functional unit of the kidney. The ureter is not a part of the kidney. Instead, it is a tube that connects the kidneys with the bladder.

Source recency: 2026

The nervous system is divided into two parts, namely ___________ and ____________.

  • aThe central nervous system and autonomic nervous system
  • bThe central nervous system and somatic nervous system
  • cThe central nervous system and peripheral nervous systemCorrect
  • dThe central nervous system and spinal cord
Rationale

The central nervous system and peripheral nervous system The nervous system is divided into the central nervous system and the peripheral nervous system. The central nervous system comprises the brain and spinal cord. The peripheral nervous system comprises the cranial nerves, spinal nerves, peripheral nerves and ganglia. Functionally, the peripheral nervous system can be classified into the: Somatic nervous system (voluntary): They innervate skeletal muscle. Autonomic nervous system (involuntary): They innervate smooth muscle, cardiac muscle, glands, and viscera. The autonomic nervous system is a part of the peripheral nervous system. The somatic nervous system is a part of the peripheral nervous system. The spinal cord is a part of the central nervous system.

Source recency: 2026

The specialized junction from which nerve impulses pass from one neuron to the next is called a _______________________.

  • aSynapseCorrect
  • bAxon terminal
  • cDendrite
  • dNode of Ranvier
Rationale

Synapse A synapse is a specialized junction between two nerves. Impulses can move from one nerve (presynaptic neuron) to another (postsynaptic neuron) via neurotransmitters in a chemical synapse, as described below: An impulse arrives at the presynaptic neuron. Calcium moves into the axon terminals and causes the synaptic vesicles to fuse with the presynaptic membrane. Neurotransmitters are released into the synaptic gap. The neurotransmitters bind to the receptors on the postsynaptic neuron, leading to the generation of an impulse. The neurotransmitter is subsequently removed from the synapse. Another kind of synapse is the electrical synapse where ions flow from one neuron to the other through channels that connect the membranes of the presynaptic and postsynaptic neurons. The axon terminal is the extension of an axon. Neurotransmitter vesicles are stored there. The dendrites are extensions of the cell body and receive incoming impulses which they convey towards the cell body. Dendrites are shorter than axons and have many branches. Nodes of Ranvier are points on the axon of a myelinated neuron, not covered by a myelin sheath.

Source recency: 2026

Which type of bone has a diaphysis and two epiphyses?

  • aLong boneCorrect
  • bShort bone
  • cFlat bone
  • dIrregular bone
Rationale

Long bones have a shaft (diaphysis) and two ends (epiphyses). Examples are the femur, the tibia, the fibula, the ulna, the radius, and the humerus. Short bones are cuboidal with a similar length and width. Examples are the carpals and the tarsals. Flat bones are thin and flat. Examples are the sternum, ribs, scapula, and bones of the skull, such as the occipital bone, the parietal bone, the frontal bone, etc. Irregular bones have an irregular shape. They consist mainly of spongy bone with a thin layer of compact bone. Examples are the vertebrae of our spine. You may use the chart below when reviewing the different types of bones: Name Description Examples Long bones Consists of a shaft and two extremities (epiphyses) which are covered by cartilage Femur, tibia, fibula, humerus, ulna, radius, clavicle, phalanges, metacarpals, and metatarsals Short bones Cuboidal with similar length and width Carpals, tarsals Flat bones Thin and broad Sternum, ribs, scapula, occipital bone, parietal bone, frontal bone Irregular bones Irregular in shape Vertebrae, hip bone, sacrum, coccyx, maxilla, mandible, temporal bone, sphenoid bone, zygomatic bone, hyoid bone Sesamoid bone Small bones within tendons Patella

Source recency: 2026

Which of the following is not found in the vertebral column?

  • aAtlas
  • bAxis
  • cCoccyx
  • dVomerCorrect
Rationale

The vomer is a small bone in the skull that separates the nasal cavity.  The vertebral column consists of cervical vertebrae, thoracic vertebrae, lumbar vertebrae, the sacrum, and the coccyx. The atlas and axis are the first and second cervical vertebrae, respectively.

Source recency: 2026

Which of the following correctly describes the function of luteinizing hormone?

  • aIt stimulates the production of testosterone in malesCorrect
  • bIt stimulates spermatogenesis in males
  • cIt stimulates the maturation of the ovarian follicle in females
  • dIt stimulates the proliferative phase of the menstrual cycle in females
Rationale

The luteinizing hormone stimulates the Leydig cells to produce testosterone in males. In females, it stimulates ovulation.   FSH stimulates spermatogenesis in males and the maturation of the ovarian follicle in females.   Estrogen stimulates the proliferative phase of the menstrual cycle in females.

Source recency: 2026

Which of the following statements is incorrect about estrogen?

  • aIt is responsible for the female secondary sex characteristics
  • bIt is produced by the cells of the ovarian follicle
  • cIt stimulates ovulationCorrect
  • dIt stimulates the proliferative phase of the menstrual cycle
Rationale

Luteinizing hormone (LH) stimulates ovulation.    Estrogen is the sex hormone responsible for the female secondary sex characteristics,  such as:   development of breasts widening of hips axillary and pubic hair   Estrogen is produced by the granulosa cells of the ovarian follicle. In addition to the secondary sex characteristics, estrogen has the following roles in the menstrual cycle: It stimulates the thickening of the endometrium before ovulation (proliferative phase of the menstrual cycle). It stimulates the release of FSH in the first half of the menstrual cycle. It triggers an LH surge.

Source recency: 2026

Which of the following is a function of a neutrophil?

  • aProduction of antibodies
  • bPhagocytosis of bacteriaCorrect
  • cInitiating allergic response
  • dElimination of protozoa
Rationale

Phagocytosis of bacteria. Neutrophils phagocytose and destroy bacteria and other pathogens. They are the most numerous white blood cells and are often the first cells to respond during an infection. B lymphocytes produce antibodies. Basophils and eosinophils are involved in allergic reactions. Eosinophils help eliminate parasites and protozoa from the body.

Source recency: 2026

Which of the following structure-function is incorrectly paired?

  • aThymus—maturation of T lymphocyte
  • bRed bone marrow—Production of B lymphocyte
  • cYellow bone marrow—Production of plateletsCorrect
  • dSpleen—Filters blood
Rationale

Yellow bone marrow, Production of platelets. The yellow bone marrow does not produce platelets; instead, it stores fat.  The red bone marrow produces platelets. T cells mature in the thymus although they are produced in the red bone marrow. The red bone marrow produces erythrocytes, leukocytes, and thrombocytes. The spleen filters and traps pathogens and damaged cells, which it presents to the immune cells.

Source recency: 2026

The bolus is formed in which part of the digestive system?

  • aOral cavityCorrect
  • bPharynx
  • cEsophagus
  • dStomach
Rationale

Oral cavity is the correct answer.    In the oral cavity, the teeth tear and grind food into small bits. Saliva moistens the food and the tongue helps to move the food and roll it into a bolus. Thereafter, the tongue moves the bolus to the back of the oral cavity where it is swallowed.    There are 3 stages of swallowing: The oral stage, which is voluntary and achieved when the tongue sends the bolus to the back of the oral cavity. The pharyngeal stage, which is involuntary. Muscles of the pharynx contract and propel the bolus into the esophagus. The esophageal stage, which is involuntary. The presence of the bolus in the esophagus initiates peristalsis that propels the bolus into the stomach.

Source recency: 2026

Which of the following correctly describes chyme?

  • aPartially digested food mixed with saliva
  • bPartially digested food mixed with gastric juiceCorrect
  • cPartially digested food mixed with an intestinal secretion
  • dPartially digested food mixed with pancreatic secretions
Rationale

Partially digested food mixed with gastric juice is the correct answer.    Chyme is partially digested food mixed with gastric juice. The bolus formed in the oral cavity is propelled to the pharynx, then the esophagus, and finally into the stomach. The stomach mixes the bolus with gastric juice through repeated contractions to form chyme.

Source recency: 2026

What is the function of the small intestine?

  • aAbsorption of nutrientsCorrect
  • bMastication
  • cCompaction of waste to feces
  • dPropulsion of feces to the rectum
Rationale

Absorption of nutrients.    The small intestine lies between the stomach and the large intestine. The mucosa of the small intestine has finger-like projections called villi, and the mucosa is also thrown into folds called plicae circulares. The villi and plicae circulares increase the surface area for absorption of nutrients.    The small intestine  is composed of 3 parts: Duodenum Jejunum Ileum   The small intestine receives chyme from the stomach, bile from the liver, and pancreatic enzymes from the pancreas. It mixes chyme, bile, intestinal secretions, and pancreatic juice together. The  small intestine breaks down chyme, absorbs nutrients, and propels the waste to the large intestine.   Mastication is the process by which the teeth break down food particles in the oral cavity.   Compaction of waste to feces occurs in the large intestine. The sigmoid colon propels feces to the rectum.

Source recency: 2026

The pectoralis major pulls the arm towards the midline. This movement is called _________.

  • aFlexion
  • bAbduction
  • cAdductionCorrect
  • dSupination
Rationale

Adduction.  Adduction pulls towards the midline. Flexion reduces the angle at a joint. Abduction pulls away from the midline.  Supination rotates the forearm so that the palm faces anteriorly. Term Definition Flexion Reduces the angle at a joint Extension Increases the angle at a joint Adduction Movement towards the midline Abduction Movement away from the midline Supination Rotates forearm so that the palm faces anteriorly Pronation Rotates forearm so that the palm faces posteriorly Inversion Turns the sole inwards Eversion Turns the sole outwards Internal (medial) rotation Rotates the anterior surface towards the midline External (lateral) rotation Rotates the anterior surface away from the midline

Source recency: 2026

What is the role of calcium in muscle contraction?

  • aCalcium binds to tropomyosin and leads to the uncovering of the active site of actin
  • bCalcium binds to troponin and leads to the uncovering of the active site of actinCorrect
  • cCalcium binds to myosin to initiate the formation of cross-bridges between myosin and actin
  • dCalcium binds to actin to initiate the formation of cross-bridges between myosin and actin
Rationale

Calcium binds to troponin and leads to the uncovering of the active site of actin.  Calcium binds to troponin and this causes tropomyosin to uncover the binding sites on the actin filament to which myosin can bind. The process of muscle contraction is described below: An action potential arrives at the neuromuscular junction The sarcoplasmic reticulum releases calcium molecules Calcium binds to troponin, which leads to the active site of actin being exposed The myosin head full of energy from cleaved ATP  binds to actin and forms cross bridges The myosin tugs on actin and moves it towards the midline leading to contraction and shortening of the sarcomere ADP is released and new ATP binds to myosin The myosin head detaches, cleaves the ATP, and is ready to begin the cycle again

Source recency: 2026

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